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As Head of Commercial, you will be a key member of the US leadership team, reporting to the President, North America. You will work closely with the broader leadership team to contribute to the commercial strategy for Egetis Therapeutics’ first rare disease launch in the US—and will be fully responsible for leading and executing the sales and marketing functions to successfully deliver that strategy. 

You’ll build and manage a lean, high-performing U.S. commercial team, establish best-in-class launch infrastructure, and oversee all field and marketing operations. Operating within a small, entrepreneurial organization, your ability to deliver results with constrained resources will be a critical success factor. The role requires strong partnership with cross-functional and global teams to ensure alignment, operational excellence, and compliance. Drawing on your rare disease expertise, you’ll lead launch planning, stakeholder engagement, and team development to drive impactful and sustainable results. 

This is a remote role based on the East Coast U.S., with preference for candidates located in or near the Boston, MA area.

Responsibilities 

Strategic Leadership and Commercial Planning  

• Support and contribute to the development and execution of commercial strategy for Egetis’ first US launch, guided by best-in-class operational practices. 

• Set clear, actionable launch milestones that balance ambitious goals with resource constraints and ensure measurable progress. 

• Build robust business cases integrating cross-functional insights and market research to evaluate market potential, forecast revenue/costs, and guide strategy and valuation. 

• Refine and drive readiness activities: Oversee brand planning, go-to-market tactics, stakeholder mapping, and demand forecasting; continuously improve forecasting models with new data. 

• Consistently analyze data and insights to inform commercial decisions, identify market opportunities, and anticipate challenges along the patient care pathway. 

• Serve as a thought leader: Share knowledge and best practices to elevate commercial capabilities, fostering a culture of operational excellence and continuous improvement. 

Sales & Marketing Execution  

• Build and lead a lean, high-performing commercial team focused on collaboration, accountability, and patient-centered service. 

• Directly manage a lean sales team, participating in field visits with key accounts to drive adoption and engagement. 

• Establish clear sales objectives and implement best-in-class reporting systems and CRM to monitor progress and optimize effectiveness. 

• Develop and implement sales team deployment plans, including setting objectives and designing compensation strategy. 

• Connect digital initiatives with field operations to maximize results, leveraging technology and real-time data collection. 

• Support individual team members in stakeholder mapping and tactical plan development. 

• Build and oversee initial commercial infrastructure, including sales and marketing; ensure smooth operationalization of the US CMLR (Commercial Medical Legal Regulatory) process. 

• Direct and oversee marketing agency collaborations, ensuring high standards and aligned messaging. 

• Develop comprehensive market research strategy to generate actionable insights supporting US commercial objectives; manage vendors and project scope. 

• Establish strong relationships with key stakeholders—HCPs, treatment sites, cross-functional partners, and vendors—to enhance credibility and drive product adoption. 

• Hire and manage key commercial partners/vendors, including market research and advertising, to support commercial goals. 

Compliance and Excellence 

• Champion best-in-class compliance with promotional, privacy, and regulatory guidelines across all commercial activities. 

• Leverage expertise in specialty pharmacy (SP) operations to ensure proper, compliant use of the product (including dosing as per label), developing tools to empower the sales team with critical prescriber-facing information. 

• Model a culture of operational excellence, embracing leading-edge technologies and innovative ideas in structuring field and commercial operations to maximize impact. 

Desired Experience and Skills:   

Experience:  

• Direct experience with launching rare disease, orphan drugs in the US. 

• At least 10+ years of progressive experience in commercial roles within pharmaceutical or biotech companies, including several years in leadership or sales management positions, with a proven ability to deliver results in both large and small organizational settings. Demonstrated success in resource-constrained, entrepreneurial environments is critical. 

• Proven track record of building and scaling high-performing commercial teams, particularly in field sales and marketing in rare disease. 

• Experience partnering with functions such as Medical Affairs, Market Access, Regulatory, and Patient Services to deliver integrated launch strategies. 

• Demonstrated success in driving cross-functional collaboration with market access teams, coupled with deep expertise in the U.S. healthcare landscape, including patient access programs, reimbursement frameworks, payer engagement, and market dynamics for rare diseases 

• Successful management of external agencies, vendors, and complex projects related to market research, marketing, and commercialization. 

Skills: 

• Ability to balance long-term strategic planning with hands-on, day-to-day commercial execution; translate strategy into actionable sales and marketing plans. 

• Inspirational leadership, strong coaching skills, ability to recruit, retain, and develop talent; foster high standards of performance and collaboration. 

• Skilled at using data, insights, and forecasting to inform business decisions and measure outcomes. 

• Deep understanding of market dynamics, patient journey, pricing strategies, and commercial modeling for rare diseases. 

• Strong organizational, project management, and problem-solving capabilities, including the ability to manage multiple priorities and deadlines. 

• Exceptional written, verbal, and presentation abilities; skill in stakeholder engagement across HCPs, KOLs, internal teams, and external partners. 

• Expertise in designing and running compliant commercial operations, leveraging best-in-class processes, technologies, and innovative approaches. 

• Competence in CRM systems, digital marketing, data platforms, and tech-enabled field execution. 

• Thorough knowledge of US promotional, privacy, and regulatory guidelines in rare disease commercialization. 

Job Summary

The Regional Medical Director (RMD) is a field-based medical/scientific expert who is responsible for educating multiple stakeholders about Egetis Therapeutics’ science and data.   With a primary focus on developing impactful external relationships and conducting fair and balanced exchange of medical information with thought leaders (TLs) healthcare professionals (HCPs), this position plays an important role in clinical trial execution, potential product launches, and potential new pipeline programs and is instrumental to Egetis’s efforts to develop new treatments for patients with rare diseases.  

You will be joining at the early stages of Egetis establishing the US Medical Affairs function and at an exciting time for the company.  As an important member of the Medical Affairs team, you will have an opportunity to contribute broadly to the success of the team and the company, as detailed below.  We are recruiting for multiple roles, generally defined as Northeast, Southeast, Midwest and West, with specific regions to be refined based on program needs and RMD locations. These roles report to the Head of Medical Affairs, North America.  Some support for non-US activities may be required.  

Responsibilities:

• As a key externally facing role, the RMD must commit to unwavering representation of Egetis’s mission as an ethical, high science, patient-focused company.
• Develop and maintain clinical, scientific, and technical expertise in relevant product and disease state areas.
• Conduct balanced medical/scientific exchange to educate health care providers (HCPs), thought leaders (TLs), payers and patient advocacy groups about Egetis’s clinical programs, to include disease state, diagnosis, mechanism of action, and data dissemination.
• Assist cross-functional Medical Communication colleagues with development, review and approval of materials required for scientific exchange.
• Contribute to development and execution of high-quality annual field medical strategic and operational plans, including HCP/TL engagement plans and congress plans.
• Supports company research initiatives across development at the request of Clinical to include, as examples: site evaluation and identification, recruitment, investigator meetings, external expert identification, accrual enhancement, and scientific and disease state education. May include support for training HCPs on appropriate administration of our products in the commercial setting, when appropriate.
• Support the development and implementation of advisory boards and other scientific meetings as needed.
• Monitor the competitive landscape for specific therapeutic areas of interest to Egetis, including current management strategies, approved products, new/emerging therapies, and differentiating features of approved/emerging competitor products. Contribute to CI plan for medical congresses.  Provide feedback internally on specific initiatives.
• As part of scientific exchange with HCPs/TLs and resulting from a deep understanding of corporate goals and program goals, be adept at identifying key insights and ensure that internal stakeholders are informed of these key insights, especially as they may pertain to successful execution of ongoing/planned clinical trials and product launches.
• As necessary, assist with training Medical Affairs and other cross-functional colleagues on disease state, diagnosis, mechanism of action, and clinical trial data for Egetis programs.
• Address unsolicited medical questions related to Egetis’s clinical programs and products in various forums e.g. regular scientific exchange, congress booths, ensuring timely, accurate and appropriate responses.
• May be requested to support Medical Information as the function develops.
• Support investigator-initiated research and grants through review, submission, evaluation, and recommendation of concepts/proposals
• Commit to unwavering compliance with Egetis’s policies and standard operating procedures and with regulatory and other ethical guidelines relevant to the RMD role and the pharmaceutical industry.
• Extensive travel consistent with RMD role, to include occasional travel to the US office in Cambridge, MA and the potential for some international travel.

Qualifications and Capabilities:

• Advanced Clinical/Science degree or professional credentials required (MD/DO, PhD, PharmD, PA, NP, MSN, RN).
• 7+ years of experience in the biotech or pharmaceutical industry in Medical Affairs, with extensive experience working in field medical
• Ability to interact and communicate effectively with multiple internal and external stakeholders. Must have extensive experience conducting formal scientific presentations.
• Strong organizational and business planning skills. Strategic thinker with creative problem-solving skills and ability to contribute to development and execution of strategic plans
• Analytical skills are essential, especially regarding understanding and interpreting scientific/clinical research/literature
• Extensive Rare Disease experience required
• Endocrinology experience preferred, experience in neurology a plus
• Drive excellence and accountability personally; promote same for Medical Affairs colleagues
• Adept, nimble, energetic and comfortable in a fast-paced, dynamic and collaborative environment
• Proven experience working in small, early-stage organization(s), with a deep understanding of the unique challenges and opportunities involved in preparing for the first product launch.
• Comfortable with a proactive hands-on approach with "rolling up one's sleeves" as necessary.